Can a registered nurse inject Botox or filler in Kentucky?

Short answer
Only if a physician, PA, dentist, or APRN has prescribed it — RN scope covers administering prescribed medication and treatment, subject to further board limits; the cited rules set no Botox- or filler-specific standard or on-site supervision requirement.

A Kentucky physician assistant may render no medical service at all without a signed, in-effect supervision agreement, and a physician may not supervise one without board approval — failing to obtain that approval is itself unprofessional conduct. The agreement must state the scope of medical services and procedures the supervising physician approves, and the level and method of supervision. Kentucky defines advanced practice registered nursing as the performance of additional acts by registered nurses who have gained advanced clinical knowledge and skills through an accredited education program preparing them for one of the four APRN roles, who are nationally certified as a certified nurse practitioner, certified registered nurse anesthetist, certified nurse midwife or clinical nurse specialist. Those additional acts, subject to approval of the board, include but are not limited to prescribing treatment, drugs and devices and ordering diagnostic tests. Registered nursing practice is defined separately and includes the administration of medication and treatment as prescribed by a physician, physician assistant, dentist, or advanced practice registered nurse, and as further authorized or limited by the board. An APRN applicant must file a written application with evidence, verified by oath, of an accredited APRN education program, national certification, English proficiency, and a passed jurisprudence examination. Effective July 15, 2026, §311.858 permits nonscheduled legend drugs and devices to the extent approved by the supervising physician. Controlled-substance prescribing and administration require at least one year of licensed PA practice, the signed application and board approval, DEA and state monitoring registration, and supervising-physician approval. Narcotic Schedule II drugs other than hydrocodone combinations are limited to 72 hours without refill; hydrocodone combinations, nonnarcotic Schedule II and Schedule III drugs to 30 days without refill. Schedule IV–V prescriptions and refills may not exceed six months; benzodiazepines and Carisoprodol are limited to 30 days without refill. Authorized PAs must complete the controlled-substance continuing education required for renewal. Independent PA practice remains prohibited.