Can a registered nurse inject Botox or filler in Delaware?

Short answer
The cited rules do not settle this — they place advanced assessment, diagnosing, prescribing and ordering in the APRN scope, not the plain RN scope, and say nothing about whether an RN may inject botulinum toxin or filler on a prescriber's order.

Delaware is an independent-practice state for advanced practice registered nurses, and says so inside the definition: advanced practice nursing is “licensed as an independent licensed practitioner” in a role and population focus approved by the Board of Nursing, and the APRN scope includes performing acts of advanced assessment, diagnosing, prescribing and ordering. The Nursing chapter sets who qualifies — an RN who has completed a graduate-level APRN program accredited by a national accrediting body and holds current certification by a national certifying body in the appropriate role and at least 1 population focus — and gives the Board of Nursing authority to grant, restrict, suspend or revoke practice or prescriptive authority.